Synthesis of Enantioenriched Amines by Iron‐Catalysed Amination of Alcohols Employing at Least One Achiral Substrate

The synthesis of a broad range enantioenriched amines by the direct Fe-catalysed coupling with alcohols through borrowing hydrogen strategy, while at least one these substrates is achiral reported. When starting from α-chiral and alcohols, wide amine products, including N-heterocyclic moieties can be obtained complete retention stereochemistry power this method demonstrated in one-step known pharmaceuticals commercially available, simple enantiopure primary alcohols. It was also found that use β-branched as reaction partners leads to partial loss stereochemical integrity final product, however, systematic optimization enabled enantiopurity possible parameters effecting for racemization were identified.